• Synthesis, Characterization and Antimicrobial Activity of N-(3-Phthalidyl)amines

    Abdulhakem R. Betrow*1, Souhaila S. Enaili2, Esmail O. Elakesh1, Ramdan M. Tarhouni3 and Adel R. Kermagi1

    1. Department of Medicinal chemistry, Faculty of Pharmacy, University of Zawia, Libya.
    2. Department of chemistry, Faculty of  Science, University of Zawia, Libya.
    3. Department of chemistry, Faculty of  Science, University of Tripoli, Libya.

    Abstract: In this research a new series of 3-(alkylanilino) phthalides are synthesized by reacting o-phthalaldehydic acid with substituted aniline in a single step and good yields. The reaction occurred selectivity at carbon no.3 of the cyclic form of the acid through the displacement of water molecules by the amine through nucleophilic substitution reaction(SN2). None of Phthalimidine product of type (C) and the Schiff bases of type (B) has been formed. All these compounds were characterized by means of their 1H-NMR, 13C-NMR, FT-IR and mass spectrometry. The synthesized products were evaluated for their antimicrobial activity. The compounds were tested for their antibacterial and antifungal activities by the ditch-plate technique..

    Keywords: syntheses, phthalides, o-phthalaldehydic acid, Antimicrobial Activity.

    Pages: 35 – 47 | Full PDF Paper