Faten Zahran, Essam Mady, Osama Yasein, Akaber T. Keshta

    Abstract: The systemic availability of curcumin is very low after oral administration; this limits their therapeutic potential. This study aims to increase the bioavailability of curcumin; the highest reproducible solubility modality will be applied on an experimental carcinogenesis models in order to evaluate its chemo-preventive, chemotherapeutic effects and antitumor potential. We found that administrating of curcumin (200 mg/kg I.P. bound to 5% BSA in PBS, pH 7.4) results in a significant inhibitory effect on tumor in vivo. An anti-oxidant effect and anti-tumor effect of curcumin in vivo was observed. A significant reduction in anti-oxidants and tumor markers levels in tumor treated animals when compared with untreated ones. As well as Bcl2 expression was reduced. Conclusion: curcumin bound BSA has a strong inhibitory activity against tumors. The anti-tumor mechanism may be mediated by preventing oxidative damage and induction of apoptosis improved animals’ chances of survival and they become healthier.

    Keywords: Curcumin, Bovine Serum albumin, Apoptosis, Hepatocellular Carcinoma.

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