One-Pot Synthesis of 3-[2-(2,4-dinitrophenyl)hydrazinyl]-2-benzofuran-1(3H)-one from o-phthalaldehydic acid and 2,4-dinitrophenylhydrazine
Dr.abdul hakim R.Beetru
Chemistry Department, Faculty of Education, Zawia University, Libya.
Abstract: An efficient and facile method for the synthesis of 3-[2-(2,4-dinitrophenyl)hydrazinyl]-2-benzofuran-1(3H)-one in a single step and very good yield (86%) by condensation of o-phthalaldehydic acid and 2,4-dinitrophenylhydrazine using a polar solvent (methanol) at room temperature, The reaction occurred selectivity at carbon no.3 of the lactol form of the o-phthalaldehydic acid acid. None of the Schiff bases of type (B) and cyclic product of type (C) have been formed. The structure of the product was confirmed from their spectral data (1H-NMR, 13C-NMR, and IR) and analytical data.
Keywords: syntheses, o-phthalaldehydic acid, condensation, phthalide.
Pages: 133 – 138 | Full PDF Paper