Antifungal Activity of Some Monoazaphenoxazine Carboxamide Derivatives

Agbo Stephen¹, Anoh Vitalis¹ and Swande Peter²

1. Organic Chemistry Unit, Department of Chemistry, Faculty of Science, Benue State University, Makurdi, Nigeria.

2. Department of Basic Sciences, Akperan Orshi College of Agriculture, Yandev, Nigeria.

Abstract: The antifungal activity of some monoazaphenoxazine carboxamide derivatives was studied against Absidia corymbifera, Epidermophyton floccosum, Fusarium solani, Trichophyton rubrum, Mucor mucedo and Penicillum specie using sabouraud’s dextrose agar. Compound 2a, 2b, and 2c showed good sensitivity against Absidia corymbifera, Epidermophyton floccosum, Fusarium solani, and Trichophyton rubrum. Compounds 2d and 2e reveal low sensitivity against Mucor mucedo and Penicillum specie. The presence of chloro-and-nitro substituents on the azaphenoxazine carboxamide ring played a significant role towards its antifungal activities.

Keywords: azaphenoxazine, carboxamide, sensitivity, Fungal, Pathogens.

Pages: 44 – 50 | Full PDF Paper