Discussions on Evaluation of Material Balance in Simulated Moving Bed Chromatography by Orthogonal Collocation Finite Elements Method

Takaki Ohkubo

Professor emeritus, Department of civil and environmental engineering, Hakodate national college of technology（〒042-8501,14-1 Tokura Hakodate Hokkaido Japan）e-mail:ohkubo@hakodate-ct.ac.jp

Abstract: This paper discusses on evaluation of material balance in simulated moving bed chromatography by using the advantage of orthogonal collocation finite elements method (OCFEM) in terms of accuracy of numerical calculation. The tool of OCFEM is differential operator represented by matrix in time and space to make it easy to translate PDEs to algebraic equations, which have high precision numerical calculation ability by high order collocation number. This study presents the dimensionless average concentration profile through the total column, and calculates the yields and purity at raffinate and extract. In conclusion, this discussion showed that the total yield at raffinate and extract is equal to 100% and the mass balance in total columns for each duration of cyclic steady condition is zero.

Keywords: Simulated Moving Bed, Chromatography, Orthogonal Collocation Finite Elements Method, differential operator, time and space, high precision, mass balance, yield at raffinate and extract.

Pages: 20 – 36 | Full PDF Paper