Markov Chain for Estimating Human Mitochondrial DNA Mutation Pattern

Sandy Vantika and Udjianna S. Pasaribu

Abstract: The Markov chain was proposed to estimate the human mitochondrial DNA mutation pattern. One DNA sequence was taken randomly from 100 sequences in Genbank. The nucleotide transition matrix and mutation transition matrix were estimated from this sequence. We determined whether the states (mutation/normal) are recurrent or transient. The results showed that both of them are recurrent.

Keywords: Estimate, Markov chain, recurrent, transient, transition matrix.

Pages: 336 – 342 | Full PDF Paper